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Battling Autoimmune Diseases: Autoimmune diseases, steroid treatment, weight gain

  • Writer: WHOSE TEA TV
    WHOSE TEA TV
  • Jul 16, 2024
  • 6 min read

Updated: Jul 21, 2024

Skinny me photo
2017 me

Introduction

Autoimmune diseases are conditions where the immune system, which typically defends the body against harmful pathogens, mistakenly attacks the body's own tissues. These diseases encompass a wide array of disorders, such as rheumatoid arthritis, lupus, and multiple sclerosis. To manage the symptoms and progression of these diseases, steroids (corticosteroids) are often prescribed. While effective in reducing inflammation and suppressing the immune response, steroid use can lead to significant side effects, one of the most concerning being weight gain.

In this comprehensive discussion, we will explore autoimmune diseases, the role of steroids in their treatment, and how steroids contribute to weight gain. We will also look at strategies for managing this side effect, maintaining a healthy lifestyle, and addressing the physical and emotional challenges that come with it.



Personal Journey: A Struggle with Weight and Autoimmune Disease

I have struggled with my weight for several years. This was not due to overeating. An autoimmune disorder interrupted my life in my early twenties. Not so surprising that multiple family members have dealt with the issues as well. I started steroids early on, like Prednisone, and tried Plaquenil, which caused visual disturbances. Now, depending on the milligram, this medication can cause bloating, whether you are inflamed already is a whole other issue. Over the years, I have stockpiled my wardrobe with sizes 4-14. Yes, that is a huge jump. Can you imagine having clothes for each of the seasons in all those assorted sizes? But this is my life, or is it? After different life-changing events, my husband and I decided we were going to change our lifestyles. This was a hard decision to make when you are accustomed to eating not-so-traditional on-time meals. This meant no more eating at night and so forth.



Autoimmune Diseases: An Overview

Autoimmune diseases occur when the immune system loses the ability to differentiate between foreign invaders and the body's own cells. This malfunction can lead to various symptoms depending on the organs and tissues affected. Common autoimmune diseases include:


  1. Rheumatoid Arthritis (RA): A condition where the immune system attacks the joints, causing inflammation, pain, and eventually joint damage.

  2. Lupus (Systemic Lupus Erythematosus, SLE): A disease that can affect multiple organs, including the skin, joints, kidneys, and brain, leading to widespread inflammation and tissue damage.

  3. Multiple Sclerosis (MS): An autoimmune disorder where the immune system targets the protective covering of nerve fibers in the central nervous system, causing neurological symptoms and disability.


Without the exact cause of autoimmune diseases being known, one can only speculate the causes.


Systemic Scleroderma: A Closer Look

Systemic scleroderma, also known as systemic sclerosis, is a rare autoimmune disease characterized by hardening and tightening of the skin and connective tissues. It can affect the skin, blood vessels, internal organs, and the digestive system. Symptoms vary widely but often include Raynaud's phenomenon (a condition where fingers and toes turn white or blue in response to cold or stress), skin thickening, and organ dysfunction. The exact cause of systemic scleroderma remains unknown, but it involves an overproduction of collagen. Treatment focuses on managing symptoms and preventing complications.


Steroids in the Treatment of Autoimmune Diseases

Corticosteroids, commonly referred to as steroids, are synthetic drugs that closely resemble cortisol, a hormone produced by the adrenal glands. They are potent anti-inflammatory agents and immune suppressants, making them highly effective in managing autoimmune diseases. Steroids are used to:


  • Reduce Inflammation: They help decrease swelling, redness, and pain in affected tissues.

  • Suppress the Immune System: By dampening the immune response, steroids prevent the immune system from attacking the body's own tissues. Commonly prescribed steroids include prednisone, methylprednisolone, and dexamethasone. While these medications are invaluable in controlling autoimmune disease symptoms, they come with a range of potential side effects, including increased appetite and weight gain.



Mechanisms of Steroid-Induced Weight Gain


At the zoo with my g kids. They took the photo
After the big C

Weight gain associated with steroid use, attributed to distinct factors:


  1. Increased Appetite: Steroids can stimulate the appetite, leading to increased calorie intake. Patients often report a heightened sense of hunger and difficulty feeling full.

  2. Fluid Retention: Steroids can cause the body to retain sodium and water, leading to bloating and weight gain. This is often referred to as "water weight."

  3. Altered Metabolism: Steroids can change how the body stores fat, particularly promoting fat deposition in the abdomen, face, and neck. This pattern of weight gain is often called "Cushingoid" appearance, resembling Cushing's syndrome.

  4. Reduced Physical Activity: The underlying autoimmune disease, along with the fatigue and joint pain associated with it, can reduce physical activity levels, contributing to weight gain.


Managing Steroid-Related Weight Gain

While weight gain from steroid use can be challenging, there are strategies to manage it effectively:


Dietary Modifications:


  • Eat organic food when possible and limit meat intake.

  • Monitor portion sizes and avoid high-calorie, low-nutrient foods.

  • Stay hydrated and limit salt intake to reduce fluid retention.


    Regular Exercise:

  • Engage in regular physical activity tailored to your ability and energy levels. Low-impact exercises like walking, swimming, or yoga can be beneficial.

  • Strength training can help maintain muscle mass, which can be lost due to steroid use and inactivity.


    Medication Management:

  • Work with your healthcare provider to find the lowest effective dose of steroids.

  • Explore alternative medications or treatments that might reduce the need for steroids.


    Emotional Support:

  • Weight gain can be distressing and impact self-esteem. Seeking support from friends, family, or a therapist can be helpful.

  • Joining support groups for individuals with autoimmune diseases can provide a sense of community and shared experiences.


Comparison Table: Effects of Steroid Use

Impact Area

Before Steroid Use

After Steroid Use

Appetite

Normal

Increased

Metabolism

Normal

Slowed

Water/Salt Retention

Normal

High

Fat Distribution

Even

Centralized (Abdomen, Face, Neck)


Living with Autoimmune Disease and Steroid Use

Navigating life with an autoimmune disease and the side effects of steroid treatment requires a comprehensive approach. It is not just about managing the physical symptoms but also addressing the emotional and psychological impact.


  1. Understanding Your Condition:

  • Educate yourself about your specific autoimmune disease. Knowledge empowers you to make informed decisions about your treatment and lifestyle.

  • Stay informed about new research and treatment options. Advances in medicine are continually made, offering hope for better management strategies.

  1. Building a Support Network:

  • Surround yourself with supportive individuals who understand your journey. This can include family, friends, healthcare providers, and support groups.

  • Communicate openly with your healthcare team. Regular check-ins and honest conversations about your symptoms and side effects are crucial.

  1. Focusing on Mental Health:

  • Autoimmune diseases and their treatments can take a toll on mental health. Stress, anxiety, and depression are common and should not be ignored.

  • Practice mindfulness, meditation, or other relaxation techniques to manage stress. These practices can improve overall health and help in coping with chronic illness.

  1. Adapting Your Lifestyle:

  • Adjust your daily routine to accommodate your energy levels and physical capabilities. Pacing yourself can prevent burnout and exacerbation of symptoms.

  • Prioritize activities that bring you joy and fulfillment. Maintaining a sense of purpose and engagement in life is vital for mental health.



Looking Forward: Future Directions in Autoimmune Disease Treatment

The field of autoimmune disease treatment is rapidly evolving. Researchers are exploring new therapies that aim to manage symptoms more effectively with fewer side effects. Promising areas include:

  1. Biologic Drugs:

  • These are targeted therapies designed to interfere with specific components of the immune system. They have shown great promise in treating autoimmune diseases with a potentially lower risk of widespread side effects compared to traditional steroids.

  1. Gene Therapy:

  • Research is underway to develop gene therapies that could correct the underlying genetic causes of autoimmune diseases. While still in the experimental stage, this approach holds significant potential for the future.

  1. Lifestyle and Integrative Medicine:

  • There is increasing recognition of the role of lifestyle factors in managing autoimmune diseases. Integrative approaches that combine conventional medicine with dietary changes, exercise, and stress management techniques are gaining traction.

Sitting in the couch for this photo lol
Me today

Conclusion

Autoimmune diseases and the use of steroids to manage them present a complex interplay of benefits and challenges. While steroids are highly effective in controlling inflammation and suppressing the immune system, they can lead to weight gain and other side effects. Understanding the mechanisms behind steroid-induced weight gain and implementing strategies to manage it can help patients maintain a healthy lifestyle and improve their quality of life.

Living with an autoimmune disease requires a multifaceted approach that includes medical treatment, lifestyle adjustments, and emotional support. By staying informed, building a dedicated support network, and focusing on holistic health, individuals can navigate the challenges of their condition and thrive.

The future of autoimmune disease treatment is promising, with ongoing research and innovations aimed at providing more effective and less burdensome options. As we look forward to these advancements, it is essential to remain initiative-taking and engaged in managing our health, ensuring a balanced and fulfilling life despite the challenges posed by autoimmune diseases and their treatments.


 


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